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e2 e2 616 r d systems  (R&D Systems)


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    R&D Systems e2 e2 616 r d systems
    E2 E2 616 R D Systems, supplied by R&D Systems, used in various techniques. Bioz Stars score: 95/100, based on 77 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+ubch5a+ube2d1+protein+r+d+system/Recombinant+Human+UbcH5a%2FUBE2D1+Protein%2C+CF/pm41857001-159-28-30
    Average 95 stars, based on 77 article reviews
    e2 e2 616 r d systems - by Bioz Stars, 2026-09
    95/100 stars

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    Related Articles

    Transfection:

    Article Title: A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies MAGE-A10 Cell Signaling Technology Cat# 68978; RRID: AB_2799757 GCN5L2 Cell Signaling Technology Cat# 3305; RRID: AB_2128281 PCAF Cell Signaling Technology Cat# 3378; RRID: AB_2128409 Ubiquitin Cell Signaling Technology Cat# 20326; RRID: AB_3064918 K48-linkage Specific Polyubiquitin Cell Signaling Technology Cat# 8081; RRID: AB_10859893 K63-linkage Specific Polyubiquitin Cell Signaling Technology Cat# 5621; RRID: AB_10827985 Histone H3 Abcam Cat# ab1791; RRID: AB_302613 Histone H3K9 Abcam Cat# ab4441; RRID: AB_2118292 Histone H3K14 Abcam Cat# ab52946; RRID: AB_880442 HA tag Abcam Cat# ab9110; RRID: AB_307019 SQSTM1/p62 Abcam Cat# ab56416; RRID: AB_945626 LC3A/B Abcam Cat# ab62721; RRID: AB_956136 CDT2/RAMP Abcam Cat# ab72264; RRID: AB_1268088 DDB1 Abcam Cat# ab109027; RRID: AB_10859111 LC3 MBL International Cat# M152-3; RRID: AB_1279144 GCN5L2 Sigma-Aldrich Cat# SAB1403858; RRID: AB_10739802 CUL4A Proteintech Cat# 10693-1-AP; RRID: AB_10896455 p300 Proteintech Cat# 20695-1-AP; RRID: AB_3085614 CREBBP Proteintech Cat# 22277-1-AP; RRID: AB_3085692 CUL4B ABclonal Cat# A12696; RRID: AB_2759539 DDDDK-tag ABclonal Cat# AE063; RRID: AB_2771920 MYC-Tag ABclonal Cat# AE070; RRID: AB_2863795 His-tag ABclonal Cat# AE086; RRID: AB_3065205 c-Myc ABclonal Cat# A19032; RRID: AB_2862524 β-Tubulin ABclonal Cat# A12289; RRID: AB_2861647 GAPDH ABclonal Cat# AC002; RRID: AB_2736879 Bacterial and virus strains DH5α TransGen Cat# CD201-01 Stbl3 TransGen Cat# CD521-01 Chemicals, peptides, and recombinant proteins DMEM medium Corning Cat# 10-013-CVRC RPMI 1640 medium Gibco Cat# 21875 DMEM/F12 medium Gibco Cat# C11330500BT McCoy’s 5a medium Gibco Cat# 16600082 Fetal Bovine Serum Corning Cat# 35-081-CV 0.25% Trypsin-EDTA (1x) Gibco Cat# 25200056 Pen Strep Gibco Cat# 15140-122 Opti-MEM I (1x) Gibco Cat# 31985070 Butyrolactone 3 MedChemExpress Cat# HY-129039 Bafilomycin A1 MedChemExpress Cat# HY-100558 MG132 Sigma-Aldrich Cat# C2211 chloroquine Sigma-Aldrich Cat# C6628 Puromycin Merck Life Science Cat# 58-58-2 (Continued on next page) 18 Cell Reports 44, 116408, October 28, 2025 .. REAGENT or RESOURCE SOURCE IDENTIFIER Lipofectamine RNAiMAX Transfection Reagent Invitrogen Cat# 13778150 Effectene Transfection Reagent QIAGEN Cat# 301427 Proteinase inhibitor cocktail NCM Cat# P001 Pierce Protein A/G Magnetic Beads Thermo Scientifc Cat# 88802 Pierce IP lysis buffer Thermo Scientifc Cat# 87787 Lipofectamine RNAiMAX Transfection Reagent Invitrogen Cat# 13778150 DAPI Abcam Cat# ab104139 Matrigel Corning Cat# 354234 Crystal violet Beyotime Cat# C0121 Recombinant Human His6-Ubiquitin E1 Enzyme R&D system Cat# E− 304-050 Recombinant Human UbcH5a/UBE2D1 Protein R&D system Cat# E2-616-100 Recombinant Human CUL1/RBX1 Neddylated Complex Protei R&D system Cat# E3-411-025 MgATP Solution R&D system Cat# B-20 Recombinant Human Ubiquitin Protein R&D system Cat# U-100H-10M Critical commercial assays TUBE LifeSensors Cat# UM502M K48 TUBE LifeSensors Cat# UM-0407M K63 TUBE LifeSensors Cat# UM-0404M Cell Counting Kit-8 MedChemExpress Cat# HY-K0301 ECL Enhanced Plus Kit Abclonal Cat# RM00021P Pierce BCA Protein Assay Kit Thermo Scientifc Cat# 23225 Deposited data Mass spectrometry raw data ProteomeXchange Consortium via the iProX partner repository PXD067966 Experimental models: Cell lines A375 ATCC Cat# CRL-1619; RRID: CVCL_0132 SK-MEL-2 ATCC Cat# HTB-68; RRID: CVCL_0069 HCT116 ATCC Cat# CCL-247EMT; RRID: CVCL_0291 HeLa ATCC Cat# CRM-CCL-2; RRID: CVCL_0030 H446 ATCC Cat# HTB-171; RRID: CVCL_1562 H460 ATCC Cat# HTB-177; RRID: CVCL_0459 H1975 ATCC Cat# CRL-5908; RRID: CVCL_1511 H1299 ATCC Cat# CRL-5803; RRID: CVCL_0060 H2126 ATCC Cat# CCL-256; RRID: CVCL_1532 H1650 ATCC Cat# CRL-5883; RRID: CVCL_1483 M059K ATCC Cat# CRL-2365; RRID: CVCL_0401 U2OS ATCC Cat# HTB-96; RRID: CVCL_0042 Experimental models: Organisms/strains BALB/c nude mice GemPharmatech Co., Ltd RRID: mgi:5654397 Oligonucleotides siRNA targeting NC Forward: 5’ -UUCUCCGAACGUGUCACGUTT-3′ Reverse: 5′- ACGUGACACGUUCGGAGAATT-3′ OBiO Technology N/A (Continued on next page) Cell Reports 44, 116408, October 28, 2025 19 .. REAGENT or RESOURCE SOURCE IDENTIFIER siRNA targeting DTL Forward: 5 ′ -GGCUCUACUUUAUUUGCUAAUTT-3 ′ Reverse: 5 ′ -AUUAGCAAAUAAAGUAGAGCCTT-3 ′ OBiO Technology N/A siRNA targeting CUL4A Forward: 5 ′ - CCUAUGUGCUGCAGAACUCTT-3 ′ Reverse: 5 ′ -GAGUUCUGCAGCACAUAGGTT-3 ′ OBiO Technology N/A siRNA targeting CUL4B Forward: 5 ′ - GCUAAGUAUGUAGAUUCAATT-3 ′ Reverse: 5 ′ - UUGAAUCUACAUACUUAGCTT-3 ′ OBiO Technology N/A siRNA targeting p62 Forward: 5 ′ -GAUCUGCGAUGGCUGCAAUTT-3 ′ Reverse: 5 ′ - AUUGCAGCCAUCGCAGAUCTT-3 ′ OBiO Technology N/A siRNA targeting DDB1 Forward: 5 ′ -ACACGAGAUUAGAGAUCUAUGTT-3 ′ Reverse: 5 ′ -CAUAGAUCUCUAAUCUCGUGUTT-3 ′ OBiO Technology N/A gRNAs targeting MAGE-10 #1: 5 ′ -GGCATGCAGCGCTGACGCTT-3 ′ #2: 5 ′ -AGCATCCTCCTCCACAGCCA-3 ′ Sangon N/A gRNAs targeting KAT2A 5 ′ -GGAUGAGAUAAACCGACUGC-3 ′ Sangon N/A Recombinant DNA pCS2-myc-MAGE A10 This paper N/A pCS2-HA-MAGE A10 This paper N/A pCS2-myc-MAGE A10 1–140Δ This paper N/A pCS2-myc-MAGE A10 141–306Δ This paper N/A pCS2-myc-MAGE A10 307–369Δ This paper N/A pCS2-myc-MAGE A10 141-306 This paper N/A pCS2-HA-KAT2A This paper N/A pCS2-myc-KAT2A This paper N/A pCS2-myc-KAT2A 1-502 This paper N/A pCS2-myc-KAT2A 503-656 This paper N/A pCS2-myc-KAT2A 657-837 This paper N/A pCS2-myc-KAT2A 1-656 This paper N/A pCS2-myc-KAT2A 503-837 This paper N/A pCS2-myc-KAT2A 503-837 This paper N/A pCS2-myc-KAT2A 657-744Δ This paper N/A pCS2-myc-KAT2A 745-815Δ This paper N/A pCS2-myc-KAT2A 816-837Δ This paper N/A pCS2-myc-KAT2A 657-686Δ This paper N/A pCS2-myc-KAT2A 687-716Δ This paper N/A pCS2-myc-KAT2A 717-744Δ This paper N/A pCS2-myc-KAT2A K446R This paper N/A pCS2-myc-KAT2A K721R K728R K759R This paper N/A (Continued on next page) 20 Cell Reports 44, 116408, October 28, 2025

    Magnetic Beads:

    Article Title: A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies MAGE-A10 Cell Signaling Technology Cat# 68978; RRID: AB_2799757 GCN5L2 Cell Signaling Technology Cat# 3305; RRID: AB_2128281 PCAF Cell Signaling Technology Cat# 3378; RRID: AB_2128409 Ubiquitin Cell Signaling Technology Cat# 20326; RRID: AB_3064918 K48-linkage Specific Polyubiquitin Cell Signaling Technology Cat# 8081; RRID: AB_10859893 K63-linkage Specific Polyubiquitin Cell Signaling Technology Cat# 5621; RRID: AB_10827985 Histone H3 Abcam Cat# ab1791; RRID: AB_302613 Histone H3K9 Abcam Cat# ab4441; RRID: AB_2118292 Histone H3K14 Abcam Cat# ab52946; RRID: AB_880442 HA tag Abcam Cat# ab9110; RRID: AB_307019 SQSTM1/p62 Abcam Cat# ab56416; RRID: AB_945626 LC3A/B Abcam Cat# ab62721; RRID: AB_956136 CDT2/RAMP Abcam Cat# ab72264; RRID: AB_1268088 DDB1 Abcam Cat# ab109027; RRID: AB_10859111 LC3 MBL International Cat# M152-3; RRID: AB_1279144 GCN5L2 Sigma-Aldrich Cat# SAB1403858; RRID: AB_10739802 CUL4A Proteintech Cat# 10693-1-AP; RRID: AB_10896455 p300 Proteintech Cat# 20695-1-AP; RRID: AB_3085614 CREBBP Proteintech Cat# 22277-1-AP; RRID: AB_3085692 CUL4B ABclonal Cat# A12696; RRID: AB_2759539 DDDDK-tag ABclonal Cat# AE063; RRID: AB_2771920 MYC-Tag ABclonal Cat# AE070; RRID: AB_2863795 His-tag ABclonal Cat# AE086; RRID: AB_3065205 c-Myc ABclonal Cat# A19032; RRID: AB_2862524 β-Tubulin ABclonal Cat# A12289; RRID: AB_2861647 GAPDH ABclonal Cat# AC002; RRID: AB_2736879 Bacterial and virus strains DH5α TransGen Cat# CD201-01 Stbl3 TransGen Cat# CD521-01 Chemicals, peptides, and recombinant proteins DMEM medium Corning Cat# 10-013-CVRC RPMI 1640 medium Gibco Cat# 21875 DMEM/F12 medium Gibco Cat# C11330500BT McCoy’s 5a medium Gibco Cat# 16600082 Fetal Bovine Serum Corning Cat# 35-081-CV 0.25% Trypsin-EDTA (1x) Gibco Cat# 25200056 Pen Strep Gibco Cat# 15140-122 Opti-MEM I (1x) Gibco Cat# 31985070 Butyrolactone 3 MedChemExpress Cat# HY-129039 Bafilomycin A1 MedChemExpress Cat# HY-100558 MG132 Sigma-Aldrich Cat# C2211 chloroquine Sigma-Aldrich Cat# C6628 Puromycin Merck Life Science Cat# 58-58-2 (Continued on next page) 18 Cell Reports 44, 116408, October 28, 2025 .. REAGENT or RESOURCE SOURCE IDENTIFIER Lipofectamine RNAiMAX Transfection Reagent Invitrogen Cat# 13778150 Effectene Transfection Reagent QIAGEN Cat# 301427 Proteinase inhibitor cocktail NCM Cat# P001 Pierce Protein A/G Magnetic Beads Thermo Scientifc Cat# 88802 Pierce IP lysis buffer Thermo Scientifc Cat# 87787 Lipofectamine RNAiMAX Transfection Reagent Invitrogen Cat# 13778150 DAPI Abcam Cat# ab104139 Matrigel Corning Cat# 354234 Crystal violet Beyotime Cat# C0121 Recombinant Human His6-Ubiquitin E1 Enzyme R&D system Cat# E− 304-050 Recombinant Human UbcH5a/UBE2D1 Protein R&D system Cat# E2-616-100 Recombinant Human CUL1/RBX1 Neddylated Complex Protei R&D system Cat# E3-411-025 MgATP Solution R&D system Cat# B-20 Recombinant Human Ubiquitin Protein R&D system Cat# U-100H-10M Critical commercial assays TUBE LifeSensors Cat# UM502M K48 TUBE LifeSensors Cat# UM-0407M K63 TUBE LifeSensors Cat# UM-0404M Cell Counting Kit-8 MedChemExpress Cat# HY-K0301 ECL Enhanced Plus Kit Abclonal Cat# RM00021P Pierce BCA Protein Assay Kit Thermo Scientifc Cat# 23225 Deposited data Mass spectrometry raw data ProteomeXchange Consortium via the iProX partner repository PXD067966 Experimental models: Cell lines A375 ATCC Cat# CRL-1619; RRID: CVCL_0132 SK-MEL-2 ATCC Cat# HTB-68; RRID: CVCL_0069 HCT116 ATCC Cat# CCL-247EMT; RRID: CVCL_0291 HeLa ATCC Cat# CRM-CCL-2; RRID: CVCL_0030 H446 ATCC Cat# HTB-171; RRID: CVCL_1562 H460 ATCC Cat# HTB-177; RRID: CVCL_0459 H1975 ATCC Cat# CRL-5908; RRID: CVCL_1511 H1299 ATCC Cat# CRL-5803; RRID: CVCL_0060 H2126 ATCC Cat# CCL-256; RRID: CVCL_1532 H1650 ATCC Cat# CRL-5883; RRID: CVCL_1483 M059K ATCC Cat# CRL-2365; RRID: CVCL_0401 U2OS ATCC Cat# HTB-96; RRID: CVCL_0042 Experimental models: Organisms/strains BALB/c nude mice GemPharmatech Co., Ltd RRID: mgi:5654397 Oligonucleotides siRNA targeting NC Forward: 5’ -UUCUCCGAACGUGUCACGUTT-3′ Reverse: 5′- ACGUGACACGUUCGGAGAATT-3′ OBiO Technology N/A (Continued on next page) Cell Reports 44, 116408, October 28, 2025 19 .. REAGENT or RESOURCE SOURCE IDENTIFIER siRNA targeting DTL Forward: 5 ′ -GGCUCUACUUUAUUUGCUAAUTT-3 ′ Reverse: 5 ′ -AUUAGCAAAUAAAGUAGAGCCTT-3 ′ OBiO Technology N/A siRNA targeting CUL4A Forward: 5 ′ - CCUAUGUGCUGCAGAACUCTT-3 ′ Reverse: 5 ′ -GAGUUCUGCAGCACAUAGGTT-3 ′ OBiO Technology N/A siRNA targeting CUL4B Forward: 5 ′ - GCUAAGUAUGUAGAUUCAATT-3 ′ Reverse: 5 ′ - UUGAAUCUACAUACUUAGCTT-3 ′ OBiO Technology N/A siRNA targeting p62 Forward: 5 ′ -GAUCUGCGAUGGCUGCAAUTT-3 ′ Reverse: 5 ′ - AUUGCAGCCAUCGCAGAUCTT-3 ′ OBiO Technology N/A siRNA targeting DDB1 Forward: 5 ′ -ACACGAGAUUAGAGAUCUAUGTT-3 ′ Reverse: 5 ′ -CAUAGAUCUCUAAUCUCGUGUTT-3 ′ OBiO Technology N/A gRNAs targeting MAGE-10 #1: 5 ′ -GGCATGCAGCGCTGACGCTT-3 ′ #2: 5 ′ -AGCATCCTCCTCCACAGCCA-3 ′ Sangon N/A gRNAs targeting KAT2A 5 ′ -GGAUGAGAUAAACCGACUGC-3 ′ Sangon N/A Recombinant DNA pCS2-myc-MAGE A10 This paper N/A pCS2-HA-MAGE A10 This paper N/A pCS2-myc-MAGE A10 1–140Δ This paper N/A pCS2-myc-MAGE A10 141–306Δ This paper N/A pCS2-myc-MAGE A10 307–369Δ This paper N/A pCS2-myc-MAGE A10 141-306 This paper N/A pCS2-HA-KAT2A This paper N/A pCS2-myc-KAT2A This paper N/A pCS2-myc-KAT2A 1-502 This paper N/A pCS2-myc-KAT2A 503-656 This paper N/A pCS2-myc-KAT2A 657-837 This paper N/A pCS2-myc-KAT2A 1-656 This paper N/A pCS2-myc-KAT2A 503-837 This paper N/A pCS2-myc-KAT2A 503-837 This paper N/A pCS2-myc-KAT2A 657-744Δ This paper N/A pCS2-myc-KAT2A 745-815Δ This paper N/A pCS2-myc-KAT2A 816-837Δ This paper N/A pCS2-myc-KAT2A 657-686Δ This paper N/A pCS2-myc-KAT2A 687-716Δ This paper N/A pCS2-myc-KAT2A 717-744Δ This paper N/A pCS2-myc-KAT2A K446R This paper N/A pCS2-myc-KAT2A K721R K728R K759R This paper N/A (Continued on next page) 20 Cell Reports 44, 116408, October 28, 2025

    Lysis:

    Article Title: A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies MAGE-A10 Cell Signaling Technology Cat# 68978; RRID: AB_2799757 GCN5L2 Cell Signaling Technology Cat# 3305; RRID: AB_2128281 PCAF Cell Signaling Technology Cat# 3378; RRID: AB_2128409 Ubiquitin Cell Signaling Technology Cat# 20326; RRID: AB_3064918 K48-linkage Specific Polyubiquitin Cell Signaling Technology Cat# 8081; RRID: AB_10859893 K63-linkage Specific Polyubiquitin Cell Signaling Technology Cat# 5621; RRID: AB_10827985 Histone H3 Abcam Cat# ab1791; RRID: AB_302613 Histone H3K9 Abcam Cat# ab4441; RRID: AB_2118292 Histone H3K14 Abcam Cat# ab52946; RRID: AB_880442 HA tag Abcam Cat# ab9110; RRID: AB_307019 SQSTM1/p62 Abcam Cat# ab56416; RRID: AB_945626 LC3A/B Abcam Cat# ab62721; RRID: AB_956136 CDT2/RAMP Abcam Cat# ab72264; RRID: AB_1268088 DDB1 Abcam Cat# ab109027; RRID: AB_10859111 LC3 MBL International Cat# M152-3; RRID: AB_1279144 GCN5L2 Sigma-Aldrich Cat# SAB1403858; RRID: AB_10739802 CUL4A Proteintech Cat# 10693-1-AP; RRID: AB_10896455 p300 Proteintech Cat# 20695-1-AP; RRID: AB_3085614 CREBBP Proteintech Cat# 22277-1-AP; RRID: AB_3085692 CUL4B ABclonal Cat# A12696; RRID: AB_2759539 DDDDK-tag ABclonal Cat# AE063; RRID: AB_2771920 MYC-Tag ABclonal Cat# AE070; RRID: AB_2863795 His-tag ABclonal Cat# AE086; RRID: AB_3065205 c-Myc ABclonal Cat# A19032; RRID: AB_2862524 β-Tubulin ABclonal Cat# A12289; RRID: AB_2861647 GAPDH ABclonal Cat# AC002; RRID: AB_2736879 Bacterial and virus strains DH5α TransGen Cat# CD201-01 Stbl3 TransGen Cat# CD521-01 Chemicals, peptides, and recombinant proteins DMEM medium Corning Cat# 10-013-CVRC RPMI 1640 medium Gibco Cat# 21875 DMEM/F12 medium Gibco Cat# C11330500BT McCoy’s 5a medium Gibco Cat# 16600082 Fetal Bovine Serum Corning Cat# 35-081-CV 0.25% Trypsin-EDTA (1x) Gibco Cat# 25200056 Pen Strep Gibco Cat# 15140-122 Opti-MEM I (1x) Gibco Cat# 31985070 Butyrolactone 3 MedChemExpress Cat# HY-129039 Bafilomycin A1 MedChemExpress Cat# HY-100558 MG132 Sigma-Aldrich Cat# C2211 chloroquine Sigma-Aldrich Cat# C6628 Puromycin Merck Life Science Cat# 58-58-2 (Continued on next page) 18 Cell Reports 44, 116408, October 28, 2025 .. REAGENT or RESOURCE SOURCE IDENTIFIER Lipofectamine RNAiMAX Transfection Reagent Invitrogen Cat# 13778150 Effectene Transfection Reagent QIAGEN Cat# 301427 Proteinase inhibitor cocktail NCM Cat# P001 Pierce Protein A/G Magnetic Beads Thermo Scientifc Cat# 88802 Pierce IP lysis buffer Thermo Scientifc Cat# 87787 Lipofectamine RNAiMAX Transfection Reagent Invitrogen Cat# 13778150 DAPI Abcam Cat# ab104139 Matrigel Corning Cat# 354234 Crystal violet Beyotime Cat# C0121 Recombinant Human His6-Ubiquitin E1 Enzyme R&D system Cat# E− 304-050 Recombinant Human UbcH5a/UBE2D1 Protein R&D system Cat# E2-616-100 Recombinant Human CUL1/RBX1 Neddylated Complex Protei R&D system Cat# E3-411-025 MgATP Solution R&D system Cat# B-20 Recombinant Human Ubiquitin Protein R&D system Cat# U-100H-10M Critical commercial assays TUBE LifeSensors Cat# UM502M K48 TUBE LifeSensors Cat# UM-0407M K63 TUBE LifeSensors Cat# UM-0404M Cell Counting Kit-8 MedChemExpress Cat# HY-K0301 ECL Enhanced Plus Kit Abclonal Cat# RM00021P Pierce BCA Protein Assay Kit Thermo Scientifc Cat# 23225 Deposited data Mass spectrometry raw data ProteomeXchange Consortium via the iProX partner repository PXD067966 Experimental models: Cell lines A375 ATCC Cat# CRL-1619; RRID: CVCL_0132 SK-MEL-2 ATCC Cat# HTB-68; RRID: CVCL_0069 HCT116 ATCC Cat# CCL-247EMT; RRID: CVCL_0291 HeLa ATCC Cat# CRM-CCL-2; RRID: CVCL_0030 H446 ATCC Cat# HTB-171; RRID: CVCL_1562 H460 ATCC Cat# HTB-177; RRID: CVCL_0459 H1975 ATCC Cat# CRL-5908; RRID: CVCL_1511 H1299 ATCC Cat# CRL-5803; RRID: CVCL_0060 H2126 ATCC Cat# CCL-256; RRID: CVCL_1532 H1650 ATCC Cat# CRL-5883; RRID: CVCL_1483 M059K ATCC Cat# CRL-2365; RRID: CVCL_0401 U2OS ATCC Cat# HTB-96; RRID: CVCL_0042 Experimental models: Organisms/strains BALB/c nude mice GemPharmatech Co., Ltd RRID: mgi:5654397 Oligonucleotides siRNA targeting NC Forward: 5’ -UUCUCCGAACGUGUCACGUTT-3′ Reverse: 5′- ACGUGACACGUUCGGAGAATT-3′ OBiO Technology N/A (Continued on next page) Cell Reports 44, 116408, October 28, 2025 19 .. REAGENT or RESOURCE SOURCE IDENTIFIER siRNA targeting DTL Forward: 5 ′ -GGCUCUACUUUAUUUGCUAAUTT-3 ′ Reverse: 5 ′ -AUUAGCAAAUAAAGUAGAGCCTT-3 ′ OBiO Technology N/A siRNA targeting CUL4A Forward: 5 ′ - CCUAUGUGCUGCAGAACUCTT-3 ′ Reverse: 5 ′ -GAGUUCUGCAGCACAUAGGTT-3 ′ OBiO Technology N/A siRNA targeting CUL4B Forward: 5 ′ - GCUAAGUAUGUAGAUUCAATT-3 ′ Reverse: 5 ′ - UUGAAUCUACAUACUUAGCTT-3 ′ OBiO Technology N/A siRNA targeting p62 Forward: 5 ′ -GAUCUGCGAUGGCUGCAAUTT-3 ′ Reverse: 5 ′ - AUUGCAGCCAUCGCAGAUCTT-3 ′ OBiO Technology N/A siRNA targeting DDB1 Forward: 5 ′ -ACACGAGAUUAGAGAUCUAUGTT-3 ′ Reverse: 5 ′ -CAUAGAUCUCUAAUCUCGUGUTT-3 ′ OBiO Technology N/A gRNAs targeting MAGE-10 #1: 5 ′ -GGCATGCAGCGCTGACGCTT-3 ′ #2: 5 ′ -AGCATCCTCCTCCACAGCCA-3 ′ Sangon N/A gRNAs targeting KAT2A 5 ′ -GGAUGAGAUAAACCGACUGC-3 ′ Sangon N/A Recombinant DNA pCS2-myc-MAGE A10 This paper N/A pCS2-HA-MAGE A10 This paper N/A pCS2-myc-MAGE A10 1–140Δ This paper N/A pCS2-myc-MAGE A10 141–306Δ This paper N/A pCS2-myc-MAGE A10 307–369Δ This paper N/A pCS2-myc-MAGE A10 141-306 This paper N/A pCS2-HA-KAT2A This paper N/A pCS2-myc-KAT2A This paper N/A pCS2-myc-KAT2A 1-502 This paper N/A pCS2-myc-KAT2A 503-656 This paper N/A pCS2-myc-KAT2A 657-837 This paper N/A pCS2-myc-KAT2A 1-656 This paper N/A pCS2-myc-KAT2A 503-837 This paper N/A pCS2-myc-KAT2A 503-837 This paper N/A pCS2-myc-KAT2A 657-744Δ This paper N/A pCS2-myc-KAT2A 745-815Δ This paper N/A pCS2-myc-KAT2A 816-837Δ This paper N/A pCS2-myc-KAT2A 657-686Δ This paper N/A pCS2-myc-KAT2A 687-716Δ This paper N/A pCS2-myc-KAT2A 717-744Δ This paper N/A pCS2-myc-KAT2A K446R This paper N/A pCS2-myc-KAT2A K721R K728R K759R This paper N/A (Continued on next page) 20 Cell Reports 44, 116408, October 28, 2025

    Recombinant:

    Article Title: A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies MAGE-A10 Cell Signaling Technology Cat# 68978; RRID: AB_2799757 GCN5L2 Cell Signaling Technology Cat# 3305; RRID: AB_2128281 PCAF Cell Signaling Technology Cat# 3378; RRID: AB_2128409 Ubiquitin Cell Signaling Technology Cat# 20326; RRID: AB_3064918 K48-linkage Specific Polyubiquitin Cell Signaling Technology Cat# 8081; RRID: AB_10859893 K63-linkage Specific Polyubiquitin Cell Signaling Technology Cat# 5621; RRID: AB_10827985 Histone H3 Abcam Cat# ab1791; RRID: AB_302613 Histone H3K9 Abcam Cat# ab4441; RRID: AB_2118292 Histone H3K14 Abcam Cat# ab52946; RRID: AB_880442 HA tag Abcam Cat# ab9110; RRID: AB_307019 SQSTM1/p62 Abcam Cat# ab56416; RRID: AB_945626 LC3A/B Abcam Cat# ab62721; RRID: AB_956136 CDT2/RAMP Abcam Cat# ab72264; RRID: AB_1268088 DDB1 Abcam Cat# ab109027; RRID: AB_10859111 LC3 MBL International Cat# M152-3; RRID: AB_1279144 GCN5L2 Sigma-Aldrich Cat# SAB1403858; RRID: AB_10739802 CUL4A Proteintech Cat# 10693-1-AP; RRID: AB_10896455 p300 Proteintech Cat# 20695-1-AP; RRID: AB_3085614 CREBBP Proteintech Cat# 22277-1-AP; RRID: AB_3085692 CUL4B ABclonal Cat# A12696; RRID: AB_2759539 DDDDK-tag ABclonal Cat# AE063; RRID: AB_2771920 MYC-Tag ABclonal Cat# AE070; RRID: AB_2863795 His-tag ABclonal Cat# AE086; RRID: AB_3065205 c-Myc ABclonal Cat# A19032; RRID: AB_2862524 β-Tubulin ABclonal Cat# A12289; RRID: AB_2861647 GAPDH ABclonal Cat# AC002; RRID: AB_2736879 Bacterial and virus strains DH5α TransGen Cat# CD201-01 Stbl3 TransGen Cat# CD521-01 Chemicals, peptides, and recombinant proteins DMEM medium Corning Cat# 10-013-CVRC RPMI 1640 medium Gibco Cat# 21875 DMEM/F12 medium Gibco Cat# C11330500BT McCoy’s 5a medium Gibco Cat# 16600082 Fetal Bovine Serum Corning Cat# 35-081-CV 0.25% Trypsin-EDTA (1x) Gibco Cat# 25200056 Pen Strep Gibco Cat# 15140-122 Opti-MEM I (1x) Gibco Cat# 31985070 Butyrolactone 3 MedChemExpress Cat# HY-129039 Bafilomycin A1 MedChemExpress Cat# HY-100558 MG132 Sigma-Aldrich Cat# C2211 chloroquine Sigma-Aldrich Cat# C6628 Puromycin Merck Life Science Cat# 58-58-2 (Continued on next page) 18 Cell Reports 44, 116408, October 28, 2025 .. REAGENT or RESOURCE SOURCE IDENTIFIER Lipofectamine RNAiMAX Transfection Reagent Invitrogen Cat# 13778150 Effectene Transfection Reagent QIAGEN Cat# 301427 Proteinase inhibitor cocktail NCM Cat# P001 Pierce Protein A/G Magnetic Beads Thermo Scientifc Cat# 88802 Pierce IP lysis buffer Thermo Scientifc Cat# 87787 Lipofectamine RNAiMAX Transfection Reagent Invitrogen Cat# 13778150 DAPI Abcam Cat# ab104139 Matrigel Corning Cat# 354234 Crystal violet Beyotime Cat# C0121 Recombinant Human His6-Ubiquitin E1 Enzyme R&D system Cat# E− 304-050 Recombinant Human UbcH5a/UBE2D1 Protein R&D system Cat# E2-616-100 Recombinant Human CUL1/RBX1 Neddylated Complex Protei R&D system Cat# E3-411-025 MgATP Solution R&D system Cat# B-20 Recombinant Human Ubiquitin Protein R&D system Cat# U-100H-10M Critical commercial assays TUBE LifeSensors Cat# UM502M K48 TUBE LifeSensors Cat# UM-0407M K63 TUBE LifeSensors Cat# UM-0404M Cell Counting Kit-8 MedChemExpress Cat# HY-K0301 ECL Enhanced Plus Kit Abclonal Cat# RM00021P Pierce BCA Protein Assay Kit Thermo Scientifc Cat# 23225 Deposited data Mass spectrometry raw data ProteomeXchange Consortium via the iProX partner repository PXD067966 Experimental models: Cell lines A375 ATCC Cat# CRL-1619; RRID: CVCL_0132 SK-MEL-2 ATCC Cat# HTB-68; RRID: CVCL_0069 HCT116 ATCC Cat# CCL-247EMT; RRID: CVCL_0291 HeLa ATCC Cat# CRM-CCL-2; RRID: CVCL_0030 H446 ATCC Cat# HTB-171; RRID: CVCL_1562 H460 ATCC Cat# HTB-177; RRID: CVCL_0459 H1975 ATCC Cat# CRL-5908; RRID: CVCL_1511 H1299 ATCC Cat# CRL-5803; RRID: CVCL_0060 H2126 ATCC Cat# CCL-256; RRID: CVCL_1532 H1650 ATCC Cat# CRL-5883; RRID: CVCL_1483 M059K ATCC Cat# CRL-2365; RRID: CVCL_0401 U2OS ATCC Cat# HTB-96; RRID: CVCL_0042 Experimental models: Organisms/strains BALB/c nude mice GemPharmatech Co., Ltd RRID: mgi:5654397 Oligonucleotides siRNA targeting NC Forward: 5’ -UUCUCCGAACGUGUCACGUTT-3′ Reverse: 5′- ACGUGACACGUUCGGAGAATT-3′ OBiO Technology N/A (Continued on next page) Cell Reports 44, 116408, October 28, 2025 19 .. REAGENT or RESOURCE SOURCE IDENTIFIER siRNA targeting DTL Forward: 5 ′ -GGCUCUACUUUAUUUGCUAAUTT-3 ′ Reverse: 5 ′ -AUUAGCAAAUAAAGUAGAGCCTT-3 ′ OBiO Technology N/A siRNA targeting CUL4A Forward: 5 ′ - CCUAUGUGCUGCAGAACUCTT-3 ′ Reverse: 5 ′ -GAGUUCUGCAGCACAUAGGTT-3 ′ OBiO Technology N/A siRNA targeting CUL4B Forward: 5 ′ - GCUAAGUAUGUAGAUUCAATT-3 ′ Reverse: 5 ′ - UUGAAUCUACAUACUUAGCTT-3 ′ OBiO Technology N/A siRNA targeting p62 Forward: 5 ′ -GAUCUGCGAUGGCUGCAAUTT-3 ′ Reverse: 5 ′ - AUUGCAGCCAUCGCAGAUCTT-3 ′ OBiO Technology N/A siRNA targeting DDB1 Forward: 5 ′ -ACACGAGAUUAGAGAUCUAUGTT-3 ′ Reverse: 5 ′ -CAUAGAUCUCUAAUCUCGUGUTT-3 ′ OBiO Technology N/A gRNAs targeting MAGE-10 #1: 5 ′ -GGCATGCAGCGCTGACGCTT-3 ′ #2: 5 ′ -AGCATCCTCCTCCACAGCCA-3 ′ Sangon N/A gRNAs targeting KAT2A 5 ′ -GGAUGAGAUAAACCGACUGC-3 ′ Sangon N/A Recombinant DNA pCS2-myc-MAGE A10 This paper N/A pCS2-HA-MAGE A10 This paper N/A pCS2-myc-MAGE A10 1–140Δ This paper N/A pCS2-myc-MAGE A10 141–306Δ This paper N/A pCS2-myc-MAGE A10 307–369Δ This paper N/A pCS2-myc-MAGE A10 141-306 This paper N/A pCS2-HA-KAT2A This paper N/A pCS2-myc-KAT2A This paper N/A pCS2-myc-KAT2A 1-502 This paper N/A pCS2-myc-KAT2A 503-656 This paper N/A pCS2-myc-KAT2A 657-837 This paper N/A pCS2-myc-KAT2A 1-656 This paper N/A pCS2-myc-KAT2A 503-837 This paper N/A pCS2-myc-KAT2A 503-837 This paper N/A pCS2-myc-KAT2A 657-744Δ This paper N/A pCS2-myc-KAT2A 745-815Δ This paper N/A pCS2-myc-KAT2A 816-837Δ This paper N/A pCS2-myc-KAT2A 657-686Δ This paper N/A pCS2-myc-KAT2A 687-716Δ This paper N/A pCS2-myc-KAT2A 717-744Δ This paper N/A pCS2-myc-KAT2A K446R This paper N/A pCS2-myc-KAT2A K721R K728R K759R This paper N/A (Continued on next page) 20 Cell Reports 44, 116408, October 28, 2025

    Ubiquitin Proteomics:

    Article Title: A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies MAGE-A10 Cell Signaling Technology Cat# 68978; RRID: AB_2799757 GCN5L2 Cell Signaling Technology Cat# 3305; RRID: AB_2128281 PCAF Cell Signaling Technology Cat# 3378; RRID: AB_2128409 Ubiquitin Cell Signaling Technology Cat# 20326; RRID: AB_3064918 K48-linkage Specific Polyubiquitin Cell Signaling Technology Cat# 8081; RRID: AB_10859893 K63-linkage Specific Polyubiquitin Cell Signaling Technology Cat# 5621; RRID: AB_10827985 Histone H3 Abcam Cat# ab1791; RRID: AB_302613 Histone H3K9 Abcam Cat# ab4441; RRID: AB_2118292 Histone H3K14 Abcam Cat# ab52946; RRID: AB_880442 HA tag Abcam Cat# ab9110; RRID: AB_307019 SQSTM1/p62 Abcam Cat# ab56416; RRID: AB_945626 LC3A/B Abcam Cat# ab62721; RRID: AB_956136 CDT2/RAMP Abcam Cat# ab72264; RRID: AB_1268088 DDB1 Abcam Cat# ab109027; RRID: AB_10859111 LC3 MBL International Cat# M152-3; RRID: AB_1279144 GCN5L2 Sigma-Aldrich Cat# SAB1403858; RRID: AB_10739802 CUL4A Proteintech Cat# 10693-1-AP; RRID: AB_10896455 p300 Proteintech Cat# 20695-1-AP; RRID: AB_3085614 CREBBP Proteintech Cat# 22277-1-AP; RRID: AB_3085692 CUL4B ABclonal Cat# A12696; RRID: AB_2759539 DDDDK-tag ABclonal Cat# AE063; RRID: AB_2771920 MYC-Tag ABclonal Cat# AE070; RRID: AB_2863795 His-tag ABclonal Cat# AE086; RRID: AB_3065205 c-Myc ABclonal Cat# A19032; RRID: AB_2862524 β-Tubulin ABclonal Cat# A12289; RRID: AB_2861647 GAPDH ABclonal Cat# AC002; RRID: AB_2736879 Bacterial and virus strains DH5α TransGen Cat# CD201-01 Stbl3 TransGen Cat# CD521-01 Chemicals, peptides, and recombinant proteins DMEM medium Corning Cat# 10-013-CVRC RPMI 1640 medium Gibco Cat# 21875 DMEM/F12 medium Gibco Cat# C11330500BT McCoy’s 5a medium Gibco Cat# 16600082 Fetal Bovine Serum Corning Cat# 35-081-CV 0.25% Trypsin-EDTA (1x) Gibco Cat# 25200056 Pen Strep Gibco Cat# 15140-122 Opti-MEM I (1x) Gibco Cat# 31985070 Butyrolactone 3 MedChemExpress Cat# HY-129039 Bafilomycin A1 MedChemExpress Cat# HY-100558 MG132 Sigma-Aldrich Cat# C2211 chloroquine Sigma-Aldrich Cat# C6628 Puromycin Merck Life Science Cat# 58-58-2 (Continued on next page) 18 Cell Reports 44, 116408, October 28, 2025 .. REAGENT or RESOURCE SOURCE IDENTIFIER Lipofectamine RNAiMAX Transfection Reagent Invitrogen Cat# 13778150 Effectene Transfection Reagent QIAGEN Cat# 301427 Proteinase inhibitor cocktail NCM Cat# P001 Pierce Protein A/G Magnetic Beads Thermo Scientifc Cat# 88802 Pierce IP lysis buffer Thermo Scientifc Cat# 87787 Lipofectamine RNAiMAX Transfection Reagent Invitrogen Cat# 13778150 DAPI Abcam Cat# ab104139 Matrigel Corning Cat# 354234 Crystal violet Beyotime Cat# C0121 Recombinant Human His6-Ubiquitin E1 Enzyme R&D system Cat# E− 304-050 Recombinant Human UbcH5a/UBE2D1 Protein R&D system Cat# E2-616-100 Recombinant Human CUL1/RBX1 Neddylated Complex Protei R&D system Cat# E3-411-025 MgATP Solution R&D system Cat# B-20 Recombinant Human Ubiquitin Protein R&D system Cat# U-100H-10M Critical commercial assays TUBE LifeSensors Cat# UM502M K48 TUBE LifeSensors Cat# UM-0407M K63 TUBE LifeSensors Cat# UM-0404M Cell Counting Kit-8 MedChemExpress Cat# HY-K0301 ECL Enhanced Plus Kit Abclonal Cat# RM00021P Pierce BCA Protein Assay Kit Thermo Scientifc Cat# 23225 Deposited data Mass spectrometry raw data ProteomeXchange Consortium via the iProX partner repository PXD067966 Experimental models: Cell lines A375 ATCC Cat# CRL-1619; RRID: CVCL_0132 SK-MEL-2 ATCC Cat# HTB-68; RRID: CVCL_0069 HCT116 ATCC Cat# CCL-247EMT; RRID: CVCL_0291 HeLa ATCC Cat# CRM-CCL-2; RRID: CVCL_0030 H446 ATCC Cat# HTB-171; RRID: CVCL_1562 H460 ATCC Cat# HTB-177; RRID: CVCL_0459 H1975 ATCC Cat# CRL-5908; RRID: CVCL_1511 H1299 ATCC Cat# CRL-5803; RRID: CVCL_0060 H2126 ATCC Cat# CCL-256; RRID: CVCL_1532 H1650 ATCC Cat# CRL-5883; RRID: CVCL_1483 M059K ATCC Cat# CRL-2365; RRID: CVCL_0401 U2OS ATCC Cat# HTB-96; RRID: CVCL_0042 Experimental models: Organisms/strains BALB/c nude mice GemPharmatech Co., Ltd RRID: mgi:5654397 Oligonucleotides siRNA targeting NC Forward: 5’ -UUCUCCGAACGUGUCACGUTT-3′ Reverse: 5′- ACGUGACACGUUCGGAGAATT-3′ OBiO Technology N/A (Continued on next page) Cell Reports 44, 116408, October 28, 2025 19 .. REAGENT or RESOURCE SOURCE IDENTIFIER siRNA targeting DTL Forward: 5 ′ -GGCUCUACUUUAUUUGCUAAUTT-3 ′ Reverse: 5 ′ -AUUAGCAAAUAAAGUAGAGCCTT-3 ′ OBiO Technology N/A siRNA targeting CUL4A Forward: 5 ′ - CCUAUGUGCUGCAGAACUCTT-3 ′ Reverse: 5 ′ -GAGUUCUGCAGCACAUAGGTT-3 ′ OBiO Technology N/A siRNA targeting CUL4B Forward: 5 ′ - GCUAAGUAUGUAGAUUCAATT-3 ′ Reverse: 5 ′ - UUGAAUCUACAUACUUAGCTT-3 ′ OBiO Technology N/A siRNA targeting p62 Forward: 5 ′ -GAUCUGCGAUGGCUGCAAUTT-3 ′ Reverse: 5 ′ - AUUGCAGCCAUCGCAGAUCTT-3 ′ OBiO Technology N/A siRNA targeting DDB1 Forward: 5 ′ -ACACGAGAUUAGAGAUCUAUGTT-3 ′ Reverse: 5 ′ -CAUAGAUCUCUAAUCUCGUGUTT-3 ′ OBiO Technology N/A gRNAs targeting MAGE-10 #1: 5 ′ -GGCATGCAGCGCTGACGCTT-3 ′ #2: 5 ′ -AGCATCCTCCTCCACAGCCA-3 ′ Sangon N/A gRNAs targeting KAT2A 5 ′ -GGAUGAGAUAAACCGACUGC-3 ′ Sangon N/A Recombinant DNA pCS2-myc-MAGE A10 This paper N/A pCS2-HA-MAGE A10 This paper N/A pCS2-myc-MAGE A10 1–140Δ This paper N/A pCS2-myc-MAGE A10 141–306Δ This paper N/A pCS2-myc-MAGE A10 307–369Δ This paper N/A pCS2-myc-MAGE A10 141-306 This paper N/A pCS2-HA-KAT2A This paper N/A pCS2-myc-KAT2A This paper N/A pCS2-myc-KAT2A 1-502 This paper N/A pCS2-myc-KAT2A 503-656 This paper N/A pCS2-myc-KAT2A 657-837 This paper N/A pCS2-myc-KAT2A 1-656 This paper N/A pCS2-myc-KAT2A 503-837 This paper N/A pCS2-myc-KAT2A 503-837 This paper N/A pCS2-myc-KAT2A 657-744Δ This paper N/A pCS2-myc-KAT2A 745-815Δ This paper N/A pCS2-myc-KAT2A 816-837Δ This paper N/A pCS2-myc-KAT2A 657-686Δ This paper N/A pCS2-myc-KAT2A 687-716Δ This paper N/A pCS2-myc-KAT2A 717-744Δ This paper N/A pCS2-myc-KAT2A K446R This paper N/A pCS2-myc-KAT2A K721R K728R K759R This paper N/A (Continued on next page) 20 Cell Reports 44, 116408, October 28, 2025

    CCK-8 Assay:

    Article Title: A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies MAGE-A10 Cell Signaling Technology Cat# 68978; RRID: AB_2799757 GCN5L2 Cell Signaling Technology Cat# 3305; RRID: AB_2128281 PCAF Cell Signaling Technology Cat# 3378; RRID: AB_2128409 Ubiquitin Cell Signaling Technology Cat# 20326; RRID: AB_3064918 K48-linkage Specific Polyubiquitin Cell Signaling Technology Cat# 8081; RRID: AB_10859893 K63-linkage Specific Polyubiquitin Cell Signaling Technology Cat# 5621; RRID: AB_10827985 Histone H3 Abcam Cat# ab1791; RRID: AB_302613 Histone H3K9 Abcam Cat# ab4441; RRID: AB_2118292 Histone H3K14 Abcam Cat# ab52946; RRID: AB_880442 HA tag Abcam Cat# ab9110; RRID: AB_307019 SQSTM1/p62 Abcam Cat# ab56416; RRID: AB_945626 LC3A/B Abcam Cat# ab62721; RRID: AB_956136 CDT2/RAMP Abcam Cat# ab72264; RRID: AB_1268088 DDB1 Abcam Cat# ab109027; RRID: AB_10859111 LC3 MBL International Cat# M152-3; RRID: AB_1279144 GCN5L2 Sigma-Aldrich Cat# SAB1403858; RRID: AB_10739802 CUL4A Proteintech Cat# 10693-1-AP; RRID: AB_10896455 p300 Proteintech Cat# 20695-1-AP; RRID: AB_3085614 CREBBP Proteintech Cat# 22277-1-AP; RRID: AB_3085692 CUL4B ABclonal Cat# A12696; RRID: AB_2759539 DDDDK-tag ABclonal Cat# AE063; RRID: AB_2771920 MYC-Tag ABclonal Cat# AE070; RRID: AB_2863795 His-tag ABclonal Cat# AE086; RRID: AB_3065205 c-Myc ABclonal Cat# A19032; RRID: AB_2862524 β-Tubulin ABclonal Cat# A12289; RRID: AB_2861647 GAPDH ABclonal Cat# AC002; RRID: AB_2736879 Bacterial and virus strains DH5α TransGen Cat# CD201-01 Stbl3 TransGen Cat# CD521-01 Chemicals, peptides, and recombinant proteins DMEM medium Corning Cat# 10-013-CVRC RPMI 1640 medium Gibco Cat# 21875 DMEM/F12 medium Gibco Cat# C11330500BT McCoy’s 5a medium Gibco Cat# 16600082 Fetal Bovine Serum Corning Cat# 35-081-CV 0.25% Trypsin-EDTA (1x) Gibco Cat# 25200056 Pen Strep Gibco Cat# 15140-122 Opti-MEM I (1x) Gibco Cat# 31985070 Butyrolactone 3 MedChemExpress Cat# HY-129039 Bafilomycin A1 MedChemExpress Cat# HY-100558 MG132 Sigma-Aldrich Cat# C2211 chloroquine Sigma-Aldrich Cat# C6628 Puromycin Merck Life Science Cat# 58-58-2 (Continued on next page) 18 Cell Reports 44, 116408, October 28, 2025 .. REAGENT or RESOURCE SOURCE IDENTIFIER Lipofectamine RNAiMAX Transfection Reagent Invitrogen Cat# 13778150 Effectene Transfection Reagent QIAGEN Cat# 301427 Proteinase inhibitor cocktail NCM Cat# P001 Pierce Protein A/G Magnetic Beads Thermo Scientifc Cat# 88802 Pierce IP lysis buffer Thermo Scientifc Cat# 87787 Lipofectamine RNAiMAX Transfection Reagent Invitrogen Cat# 13778150 DAPI Abcam Cat# ab104139 Matrigel Corning Cat# 354234 Crystal violet Beyotime Cat# C0121 Recombinant Human His6-Ubiquitin E1 Enzyme R&D system Cat# E− 304-050 Recombinant Human UbcH5a/UBE2D1 Protein R&D system Cat# E2-616-100 Recombinant Human CUL1/RBX1 Neddylated Complex Protei R&D system Cat# E3-411-025 MgATP Solution R&D system Cat# B-20 Recombinant Human Ubiquitin Protein R&D system Cat# U-100H-10M Critical commercial assays TUBE LifeSensors Cat# UM502M K48 TUBE LifeSensors Cat# UM-0407M K63 TUBE LifeSensors Cat# UM-0404M Cell Counting Kit-8 MedChemExpress Cat# HY-K0301 ECL Enhanced Plus Kit Abclonal Cat# RM00021P Pierce BCA Protein Assay Kit Thermo Scientifc Cat# 23225 Deposited data Mass spectrometry raw data ProteomeXchange Consortium via the iProX partner repository PXD067966 Experimental models: Cell lines A375 ATCC Cat# CRL-1619; RRID: CVCL_0132 SK-MEL-2 ATCC Cat# HTB-68; RRID: CVCL_0069 HCT116 ATCC Cat# CCL-247EMT; RRID: CVCL_0291 HeLa ATCC Cat# CRM-CCL-2; RRID: CVCL_0030 H446 ATCC Cat# HTB-171; RRID: CVCL_1562 H460 ATCC Cat# HTB-177; RRID: CVCL_0459 H1975 ATCC Cat# CRL-5908; RRID: CVCL_1511 H1299 ATCC Cat# CRL-5803; RRID: CVCL_0060 H2126 ATCC Cat# CCL-256; RRID: CVCL_1532 H1650 ATCC Cat# CRL-5883; RRID: CVCL_1483 M059K ATCC Cat# CRL-2365; RRID: CVCL_0401 U2OS ATCC Cat# HTB-96; RRID: CVCL_0042 Experimental models: Organisms/strains BALB/c nude mice GemPharmatech Co., Ltd RRID: mgi:5654397 Oligonucleotides siRNA targeting NC Forward: 5’ -UUCUCCGAACGUGUCACGUTT-3′ Reverse: 5′- ACGUGACACGUUCGGAGAATT-3′ OBiO Technology N/A (Continued on next page) Cell Reports 44, 116408, October 28, 2025 19 .. REAGENT or RESOURCE SOURCE IDENTIFIER siRNA targeting DTL Forward: 5 ′ -GGCUCUACUUUAUUUGCUAAUTT-3 ′ Reverse: 5 ′ -AUUAGCAAAUAAAGUAGAGCCTT-3 ′ OBiO Technology N/A siRNA targeting CUL4A Forward: 5 ′ - CCUAUGUGCUGCAGAACUCTT-3 ′ Reverse: 5 ′ -GAGUUCUGCAGCACAUAGGTT-3 ′ OBiO Technology N/A siRNA targeting CUL4B Forward: 5 ′ - GCUAAGUAUGUAGAUUCAATT-3 ′ Reverse: 5 ′ - UUGAAUCUACAUACUUAGCTT-3 ′ OBiO Technology N/A siRNA targeting p62 Forward: 5 ′ -GAUCUGCGAUGGCUGCAAUTT-3 ′ Reverse: 5 ′ - AUUGCAGCCAUCGCAGAUCTT-3 ′ OBiO Technology N/A siRNA targeting DDB1 Forward: 5 ′ -ACACGAGAUUAGAGAUCUAUGTT-3 ′ Reverse: 5 ′ -CAUAGAUCUCUAAUCUCGUGUTT-3 ′ OBiO Technology N/A gRNAs targeting MAGE-10 #1: 5 ′ -GGCATGCAGCGCTGACGCTT-3 ′ #2: 5 ′ -AGCATCCTCCTCCACAGCCA-3 ′ Sangon N/A gRNAs targeting KAT2A 5 ′ -GGAUGAGAUAAACCGACUGC-3 ′ Sangon N/A Recombinant DNA pCS2-myc-MAGE A10 This paper N/A pCS2-HA-MAGE A10 This paper N/A pCS2-myc-MAGE A10 1–140Δ This paper N/A pCS2-myc-MAGE A10 141–306Δ This paper N/A pCS2-myc-MAGE A10 307–369Δ This paper N/A pCS2-myc-MAGE A10 141-306 This paper N/A pCS2-HA-KAT2A This paper N/A pCS2-myc-KAT2A This paper N/A pCS2-myc-KAT2A 1-502 This paper N/A pCS2-myc-KAT2A 503-656 This paper N/A pCS2-myc-KAT2A 657-837 This paper N/A pCS2-myc-KAT2A 1-656 This paper N/A pCS2-myc-KAT2A 503-837 This paper N/A pCS2-myc-KAT2A 503-837 This paper N/A pCS2-myc-KAT2A 657-744Δ This paper N/A pCS2-myc-KAT2A 745-815Δ This paper N/A pCS2-myc-KAT2A 816-837Δ This paper N/A pCS2-myc-KAT2A 657-686Δ This paper N/A pCS2-myc-KAT2A 687-716Δ This paper N/A pCS2-myc-KAT2A 717-744Δ This paper N/A pCS2-myc-KAT2A K446R This paper N/A pCS2-myc-KAT2A K721R K728R K759R This paper N/A (Continued on next page) 20 Cell Reports 44, 116408, October 28, 2025

    Bicinchoninic Acid Protein Assay:

    Article Title: A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies MAGE-A10 Cell Signaling Technology Cat# 68978; RRID: AB_2799757 GCN5L2 Cell Signaling Technology Cat# 3305; RRID: AB_2128281 PCAF Cell Signaling Technology Cat# 3378; RRID: AB_2128409 Ubiquitin Cell Signaling Technology Cat# 20326; RRID: AB_3064918 K48-linkage Specific Polyubiquitin Cell Signaling Technology Cat# 8081; RRID: AB_10859893 K63-linkage Specific Polyubiquitin Cell Signaling Technology Cat# 5621; RRID: AB_10827985 Histone H3 Abcam Cat# ab1791; RRID: AB_302613 Histone H3K9 Abcam Cat# ab4441; RRID: AB_2118292 Histone H3K14 Abcam Cat# ab52946; RRID: AB_880442 HA tag Abcam Cat# ab9110; RRID: AB_307019 SQSTM1/p62 Abcam Cat# ab56416; RRID: AB_945626 LC3A/B Abcam Cat# ab62721; RRID: AB_956136 CDT2/RAMP Abcam Cat# ab72264; RRID: AB_1268088 DDB1 Abcam Cat# ab109027; RRID: AB_10859111 LC3 MBL International Cat# M152-3; RRID: AB_1279144 GCN5L2 Sigma-Aldrich Cat# SAB1403858; RRID: AB_10739802 CUL4A Proteintech Cat# 10693-1-AP; RRID: AB_10896455 p300 Proteintech Cat# 20695-1-AP; RRID: AB_3085614 CREBBP Proteintech Cat# 22277-1-AP; RRID: AB_3085692 CUL4B ABclonal Cat# A12696; RRID: AB_2759539 DDDDK-tag ABclonal Cat# AE063; RRID: AB_2771920 MYC-Tag ABclonal Cat# AE070; RRID: AB_2863795 His-tag ABclonal Cat# AE086; RRID: AB_3065205 c-Myc ABclonal Cat# A19032; RRID: AB_2862524 β-Tubulin ABclonal Cat# A12289; RRID: AB_2861647 GAPDH ABclonal Cat# AC002; RRID: AB_2736879 Bacterial and virus strains DH5α TransGen Cat# CD201-01 Stbl3 TransGen Cat# CD521-01 Chemicals, peptides, and recombinant proteins DMEM medium Corning Cat# 10-013-CVRC RPMI 1640 medium Gibco Cat# 21875 DMEM/F12 medium Gibco Cat# C11330500BT McCoy’s 5a medium Gibco Cat# 16600082 Fetal Bovine Serum Corning Cat# 35-081-CV 0.25% Trypsin-EDTA (1x) Gibco Cat# 25200056 Pen Strep Gibco Cat# 15140-122 Opti-MEM I (1x) Gibco Cat# 31985070 Butyrolactone 3 MedChemExpress Cat# HY-129039 Bafilomycin A1 MedChemExpress Cat# HY-100558 MG132 Sigma-Aldrich Cat# C2211 chloroquine Sigma-Aldrich Cat# C6628 Puromycin Merck Life Science Cat# 58-58-2 (Continued on next page) 18 Cell Reports 44, 116408, October 28, 2025 .. REAGENT or RESOURCE SOURCE IDENTIFIER Lipofectamine RNAiMAX Transfection Reagent Invitrogen Cat# 13778150 Effectene Transfection Reagent QIAGEN Cat# 301427 Proteinase inhibitor cocktail NCM Cat# P001 Pierce Protein A/G Magnetic Beads Thermo Scientifc Cat# 88802 Pierce IP lysis buffer Thermo Scientifc Cat# 87787 Lipofectamine RNAiMAX Transfection Reagent Invitrogen Cat# 13778150 DAPI Abcam Cat# ab104139 Matrigel Corning Cat# 354234 Crystal violet Beyotime Cat# C0121 Recombinant Human His6-Ubiquitin E1 Enzyme R&D system Cat# E− 304-050 Recombinant Human UbcH5a/UBE2D1 Protein R&D system Cat# E2-616-100 Recombinant Human CUL1/RBX1 Neddylated Complex Protei R&D system Cat# E3-411-025 MgATP Solution R&D system Cat# B-20 Recombinant Human Ubiquitin Protein R&D system Cat# U-100H-10M Critical commercial assays TUBE LifeSensors Cat# UM502M K48 TUBE LifeSensors Cat# UM-0407M K63 TUBE LifeSensors Cat# UM-0404M Cell Counting Kit-8 MedChemExpress Cat# HY-K0301 ECL Enhanced Plus Kit Abclonal Cat# RM00021P Pierce BCA Protein Assay Kit Thermo Scientifc Cat# 23225 Deposited data Mass spectrometry raw data ProteomeXchange Consortium via the iProX partner repository PXD067966 Experimental models: Cell lines A375 ATCC Cat# CRL-1619; RRID: CVCL_0132 SK-MEL-2 ATCC Cat# HTB-68; RRID: CVCL_0069 HCT116 ATCC Cat# CCL-247EMT; RRID: CVCL_0291 HeLa ATCC Cat# CRM-CCL-2; RRID: CVCL_0030 H446 ATCC Cat# HTB-171; RRID: CVCL_1562 H460 ATCC Cat# HTB-177; RRID: CVCL_0459 H1975 ATCC Cat# CRL-5908; RRID: CVCL_1511 H1299 ATCC Cat# CRL-5803; RRID: CVCL_0060 H2126 ATCC Cat# CCL-256; RRID: CVCL_1532 H1650 ATCC Cat# CRL-5883; RRID: CVCL_1483 M059K ATCC Cat# CRL-2365; RRID: CVCL_0401 U2OS ATCC Cat# HTB-96; RRID: CVCL_0042 Experimental models: Organisms/strains BALB/c nude mice GemPharmatech Co., Ltd RRID: mgi:5654397 Oligonucleotides siRNA targeting NC Forward: 5’ -UUCUCCGAACGUGUCACGUTT-3′ Reverse: 5′- ACGUGACACGUUCGGAGAATT-3′ OBiO Technology N/A (Continued on next page) Cell Reports 44, 116408, October 28, 2025 19 .. REAGENT or RESOURCE SOURCE IDENTIFIER siRNA targeting DTL Forward: 5 ′ -GGCUCUACUUUAUUUGCUAAUTT-3 ′ Reverse: 5 ′ -AUUAGCAAAUAAAGUAGAGCCTT-3 ′ OBiO Technology N/A siRNA targeting CUL4A Forward: 5 ′ - CCUAUGUGCUGCAGAACUCTT-3 ′ Reverse: 5 ′ -GAGUUCUGCAGCACAUAGGTT-3 ′ OBiO Technology N/A siRNA targeting CUL4B Forward: 5 ′ - GCUAAGUAUGUAGAUUCAATT-3 ′ Reverse: 5 ′ - UUGAAUCUACAUACUUAGCTT-3 ′ OBiO Technology N/A siRNA targeting p62 Forward: 5 ′ -GAUCUGCGAUGGCUGCAAUTT-3 ′ Reverse: 5 ′ - AUUGCAGCCAUCGCAGAUCTT-3 ′ OBiO Technology N/A siRNA targeting DDB1 Forward: 5 ′ -ACACGAGAUUAGAGAUCUAUGTT-3 ′ Reverse: 5 ′ -CAUAGAUCUCUAAUCUCGUGUTT-3 ′ OBiO Technology N/A gRNAs targeting MAGE-10 #1: 5 ′ -GGCATGCAGCGCTGACGCTT-3 ′ #2: 5 ′ -AGCATCCTCCTCCACAGCCA-3 ′ Sangon N/A gRNAs targeting KAT2A 5 ′ -GGAUGAGAUAAACCGACUGC-3 ′ Sangon N/A Recombinant DNA pCS2-myc-MAGE A10 This paper N/A pCS2-HA-MAGE A10 This paper N/A pCS2-myc-MAGE A10 1–140Δ This paper N/A pCS2-myc-MAGE A10 141–306Δ This paper N/A pCS2-myc-MAGE A10 307–369Δ This paper N/A pCS2-myc-MAGE A10 141-306 This paper N/A pCS2-HA-KAT2A This paper N/A pCS2-myc-KAT2A This paper N/A pCS2-myc-KAT2A 1-502 This paper N/A pCS2-myc-KAT2A 503-656 This paper N/A pCS2-myc-KAT2A 657-837 This paper N/A pCS2-myc-KAT2A 1-656 This paper N/A pCS2-myc-KAT2A 503-837 This paper N/A pCS2-myc-KAT2A 503-837 This paper N/A pCS2-myc-KAT2A 657-744Δ This paper N/A pCS2-myc-KAT2A 745-815Δ This paper N/A pCS2-myc-KAT2A 816-837Δ This paper N/A pCS2-myc-KAT2A 657-686Δ This paper N/A pCS2-myc-KAT2A 687-716Δ This paper N/A pCS2-myc-KAT2A 717-744Δ This paper N/A pCS2-myc-KAT2A K446R This paper N/A pCS2-myc-KAT2A K721R K728R K759R This paper N/A (Continued on next page) 20 Cell Reports 44, 116408, October 28, 2025

    Mass Spectrometry:

    Article Title: A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies MAGE-A10 Cell Signaling Technology Cat# 68978; RRID: AB_2799757 GCN5L2 Cell Signaling Technology Cat# 3305; RRID: AB_2128281 PCAF Cell Signaling Technology Cat# 3378; RRID: AB_2128409 Ubiquitin Cell Signaling Technology Cat# 20326; RRID: AB_3064918 K48-linkage Specific Polyubiquitin Cell Signaling Technology Cat# 8081; RRID: AB_10859893 K63-linkage Specific Polyubiquitin Cell Signaling Technology Cat# 5621; RRID: AB_10827985 Histone H3 Abcam Cat# ab1791; RRID: AB_302613 Histone H3K9 Abcam Cat# ab4441; RRID: AB_2118292 Histone H3K14 Abcam Cat# ab52946; RRID: AB_880442 HA tag Abcam Cat# ab9110; RRID: AB_307019 SQSTM1/p62 Abcam Cat# ab56416; RRID: AB_945626 LC3A/B Abcam Cat# ab62721; RRID: AB_956136 CDT2/RAMP Abcam Cat# ab72264; RRID: AB_1268088 DDB1 Abcam Cat# ab109027; RRID: AB_10859111 LC3 MBL International Cat# M152-3; RRID: AB_1279144 GCN5L2 Sigma-Aldrich Cat# SAB1403858; RRID: AB_10739802 CUL4A Proteintech Cat# 10693-1-AP; RRID: AB_10896455 p300 Proteintech Cat# 20695-1-AP; RRID: AB_3085614 CREBBP Proteintech Cat# 22277-1-AP; RRID: AB_3085692 CUL4B ABclonal Cat# A12696; RRID: AB_2759539 DDDDK-tag ABclonal Cat# AE063; RRID: AB_2771920 MYC-Tag ABclonal Cat# AE070; RRID: AB_2863795 His-tag ABclonal Cat# AE086; RRID: AB_3065205 c-Myc ABclonal Cat# A19032; RRID: AB_2862524 β-Tubulin ABclonal Cat# A12289; RRID: AB_2861647 GAPDH ABclonal Cat# AC002; RRID: AB_2736879 Bacterial and virus strains DH5α TransGen Cat# CD201-01 Stbl3 TransGen Cat# CD521-01 Chemicals, peptides, and recombinant proteins DMEM medium Corning Cat# 10-013-CVRC RPMI 1640 medium Gibco Cat# 21875 DMEM/F12 medium Gibco Cat# C11330500BT McCoy’s 5a medium Gibco Cat# 16600082 Fetal Bovine Serum Corning Cat# 35-081-CV 0.25% Trypsin-EDTA (1x) Gibco Cat# 25200056 Pen Strep Gibco Cat# 15140-122 Opti-MEM I (1x) Gibco Cat# 31985070 Butyrolactone 3 MedChemExpress Cat# HY-129039 Bafilomycin A1 MedChemExpress Cat# HY-100558 MG132 Sigma-Aldrich Cat# C2211 chloroquine Sigma-Aldrich Cat# C6628 Puromycin Merck Life Science Cat# 58-58-2 (Continued on next page) 18 Cell Reports 44, 116408, October 28, 2025 .. REAGENT or RESOURCE SOURCE IDENTIFIER Lipofectamine RNAiMAX Transfection Reagent Invitrogen Cat# 13778150 Effectene Transfection Reagent QIAGEN Cat# 301427 Proteinase inhibitor cocktail NCM Cat# P001 Pierce Protein A/G Magnetic Beads Thermo Scientifc Cat# 88802 Pierce IP lysis buffer Thermo Scientifc Cat# 87787 Lipofectamine RNAiMAX Transfection Reagent Invitrogen Cat# 13778150 DAPI Abcam Cat# ab104139 Matrigel Corning Cat# 354234 Crystal violet Beyotime Cat# C0121 Recombinant Human His6-Ubiquitin E1 Enzyme R&D system Cat# E− 304-050 Recombinant Human UbcH5a/UBE2D1 Protein R&D system Cat# E2-616-100 Recombinant Human CUL1/RBX1 Neddylated Complex Protei R&D system Cat# E3-411-025 MgATP Solution R&D system Cat# B-20 Recombinant Human Ubiquitin Protein R&D system Cat# U-100H-10M Critical commercial assays TUBE LifeSensors Cat# UM502M K48 TUBE LifeSensors Cat# UM-0407M K63 TUBE LifeSensors Cat# UM-0404M Cell Counting Kit-8 MedChemExpress Cat# HY-K0301 ECL Enhanced Plus Kit Abclonal Cat# RM00021P Pierce BCA Protein Assay Kit Thermo Scientifc Cat# 23225 Deposited data Mass spectrometry raw data ProteomeXchange Consortium via the iProX partner repository PXD067966 Experimental models: Cell lines A375 ATCC Cat# CRL-1619; RRID: CVCL_0132 SK-MEL-2 ATCC Cat# HTB-68; RRID: CVCL_0069 HCT116 ATCC Cat# CCL-247EMT; RRID: CVCL_0291 HeLa ATCC Cat# CRM-CCL-2; RRID: CVCL_0030 H446 ATCC Cat# HTB-171; RRID: CVCL_1562 H460 ATCC Cat# HTB-177; RRID: CVCL_0459 H1975 ATCC Cat# CRL-5908; RRID: CVCL_1511 H1299 ATCC Cat# CRL-5803; RRID: CVCL_0060 H2126 ATCC Cat# CCL-256; RRID: CVCL_1532 H1650 ATCC Cat# CRL-5883; RRID: CVCL_1483 M059K ATCC Cat# CRL-2365; RRID: CVCL_0401 U2OS ATCC Cat# HTB-96; RRID: CVCL_0042 Experimental models: Organisms/strains BALB/c nude mice GemPharmatech Co., Ltd RRID: mgi:5654397 Oligonucleotides siRNA targeting NC Forward: 5’ -UUCUCCGAACGUGUCACGUTT-3′ Reverse: 5′- ACGUGACACGUUCGGAGAATT-3′ OBiO Technology N/A (Continued on next page) Cell Reports 44, 116408, October 28, 2025 19 .. REAGENT or RESOURCE SOURCE IDENTIFIER siRNA targeting DTL Forward: 5 ′ -GGCUCUACUUUAUUUGCUAAUTT-3 ′ Reverse: 5 ′ -AUUAGCAAAUAAAGUAGAGCCTT-3 ′ OBiO Technology N/A siRNA targeting CUL4A Forward: 5 ′ - CCUAUGUGCUGCAGAACUCTT-3 ′ Reverse: 5 ′ -GAGUUCUGCAGCACAUAGGTT-3 ′ OBiO Technology N/A siRNA targeting CUL4B Forward: 5 ′ - GCUAAGUAUGUAGAUUCAATT-3 ′ Reverse: 5 ′ - UUGAAUCUACAUACUUAGCTT-3 ′ OBiO Technology N/A siRNA targeting p62 Forward: 5 ′ -GAUCUGCGAUGGCUGCAAUTT-3 ′ Reverse: 5 ′ - AUUGCAGCCAUCGCAGAUCTT-3 ′ OBiO Technology N/A siRNA targeting DDB1 Forward: 5 ′ -ACACGAGAUUAGAGAUCUAUGTT-3 ′ Reverse: 5 ′ -CAUAGAUCUCUAAUCUCGUGUTT-3 ′ OBiO Technology N/A gRNAs targeting MAGE-10 #1: 5 ′ -GGCATGCAGCGCTGACGCTT-3 ′ #2: 5 ′ -AGCATCCTCCTCCACAGCCA-3 ′ Sangon N/A gRNAs targeting KAT2A 5 ′ -GGAUGAGAUAAACCGACUGC-3 ′ Sangon N/A Recombinant DNA pCS2-myc-MAGE A10 This paper N/A pCS2-HA-MAGE A10 This paper N/A pCS2-myc-MAGE A10 1–140Δ This paper N/A pCS2-myc-MAGE A10 141–306Δ This paper N/A pCS2-myc-MAGE A10 307–369Δ This paper N/A pCS2-myc-MAGE A10 141-306 This paper N/A pCS2-HA-KAT2A This paper N/A pCS2-myc-KAT2A This paper N/A pCS2-myc-KAT2A 1-502 This paper N/A pCS2-myc-KAT2A 503-656 This paper N/A pCS2-myc-KAT2A 657-837 This paper N/A pCS2-myc-KAT2A 1-656 This paper N/A pCS2-myc-KAT2A 503-837 This paper N/A pCS2-myc-KAT2A 503-837 This paper N/A pCS2-myc-KAT2A 657-744Δ This paper N/A pCS2-myc-KAT2A 745-815Δ This paper N/A pCS2-myc-KAT2A 816-837Δ This paper N/A pCS2-myc-KAT2A 657-686Δ This paper N/A pCS2-myc-KAT2A 687-716Δ This paper N/A pCS2-myc-KAT2A 717-744Δ This paper N/A pCS2-myc-KAT2A K446R This paper N/A pCS2-myc-KAT2A K721R K728R K759R This paper N/A (Continued on next page) 20 Cell Reports 44, 116408, October 28, 2025



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